توجه ! این یک نسخه آرشیو شده میباشد و در این حالت شما عکسی را مشاهده نمیکنید برای مشاهده کامل متن و عکسها بر روی لینک مقابل کلیک کنید : Chiral separation by combining pertraction and preferential crystallization

محمد بهبهانی
04-10-2013, 12:04 PM
a b s t r a c t
This work describes the application of a hybrid two-step enantioselective separation process. As a first
step, pertraction using supported liquid membranes provides an initial enrichment, while the following
preferential crystallization delivers the enantiopure crystals as final product. Mandelic acid in water was
studied as a model system. Using a suitable chiral selector, pertraction provides enrichments exceeding
10% and reaching up to 20% in the permeate phase, which was sufficient to allow for subsequent selective
preferential crystallization. Based on the individual performances of pertraction and crystallization,
overall yields and productivities are estimated. The calculated productivities are compared with values
achievable in alternatively applicable chromatographic separation processes using chiral stationary
phases. The realized hybrid pertraction-crystallization process is in its present state for the example considered
still inferior to preparative chromatography. Strategies for further improvement are suggested.

a r t i c l e i n f o
Article history:
Received 18 May 2012
Received in revised form 16 August 2012
Accepted 6 September 2012
Available online 15 September 2012
Liquid membrane
Preferential crystallization
Hybrid process