توجه ! این یک نسخه آرشیو شده میباشد و در این حالت شما عکسی را مشاهده نمیکنید برای مشاهده کامل متن و عکسها بر روی لینک مقابل کلیک کنید : New Insights into Understanding the Mechanisms, Pathogenesis, and Management of Malignant Mesotheliomas

محمد بهبهانی
04-10-2013, 02:55 PM
Malignant mesothelioma (MM) is a relatively rare but devastating tumor that is increasing worldwide.
Yet, because of difficulties in early diagnosis and resistance to conventional therapies, MM remains
a challenge for pathologists and clinicians to treat. In recent years, much has been revealed regarding
the mechanisms of interactions of pathogenic fibers with mesothelial cells, crucial signaling pathways,
and genetic and epigenetic events that may occur during the pathogenesis of these unusual, pleiomorphic
tumors. These observations support a scenario whereby mesothelial cells undergo a series of
chronic injury, inflammation, and proliferation in the long latency period of MM development that may
be perpetuated by durable fibers, the tumor microenvironment, and inflammatory stimuli. One culprit in
sustained inflammation is the activated inflammasome, a component of macrophages or mesothelial
cells that leads to production of chemotactic, growth-promoting, and angiogenic cytokines. This
information has been vital to designing novel therapeutic approaches for patients with MM that focus
on immunotherapy, targeting growth factor receptors and pathways, overcoming resistance to
apoptosis, and modifying epigenetic changes. (Am J Pathol 2013, 182: 1065e1077; Resolve a DOI (http://dx.doi.org/)