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موضوع: A double blind randomised controlled clinical trial comparing a novel anti-stain and calculus reducing dentifrice with a standard fluoride dentifrice

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    تاریخ عضویت
    July 2009
    رشته
    مهندسی شیمی
    نوشته ها
    514
    پسندیده
    0

    [ مورد پسند: 46 بار در 33 پست ]

    پیش فرض A double blind randomised controlled clinical trial comparing a novel anti-stain and calculus reducing dentifrice with a standard fluoride dentifrice

    a b s t r a c t
    Objectives: This clinical trial tested the anti-stain efficacy at 3 and 6 months of a novel,
    sodium polyaspartate-containing, anti-stain dentifrice. In addition, the efficacy of the new
    dentifrice in controlling gingival inflammation and inhibition of calculus deposition was
    tested.
    Methods: Participants were recruited to this double blind randomised control clinical trial,
    and allocated to either test or control groups. The presence of stain and calculus were entry
    criteria. Measurements of stain, calculus and gingival inflammation were recorded using the
    Shaw and Murray Stain score, Volpe-Manhold Calculus score and the Modified Gingival
    Index respectively. Measurements were made at baseline, prior to the removal of stain and
    calculus, and after 3 and 6 months. Missing data were imputed by and the outcomes were
    analysed using univariate analysis.
    Results: At three months, toothpaste containing sodium polyaspartate was better (difference
    of mean 1.13 with SEM 0.57) than control for the control of dental stain ( p < 0.05). Stain
    scores also showed a trend in favour of the test product (difference of mean 1.03 with SEM
    0.78) at six months ( p > 0.05). There was no difference between toothpastes with respect to
    calculus deposition or gingival inflammation.
    Conclusions: Toothpaste containing sodium polyaspartate was more effective than a control
    toothpaste at preventing deposition of dental stain for 3 months after professional tooth
    cleaning but showed no significant effect at 6 months.
    Clinical relevance: Sodium polyaspartate toothpaste was more effective than a control
    toothpaste at preventing dental stain formation and maybe helpful in controlling staining
    between episodes of scaling and polishing

    a r t i c l e i n f o
    Article history:
    Received 9 November 2011
    Received in revised form
    1 November 2012
    Accepted 10 December 2012
    Keywords:
    Toothpaste
    Sodium polyaspartate
    Dental calculus
    Gingivitis
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