( مشاهده پاسخ شماره 1 تا 1 / از مجموع 1 پاسخ )

موضوع: Regulation of IL-17 Family Members by Adrenal Hormones During Experimental Sepsis in Mice

  1. #1

    تاریخ عضویت
    July 2009
    رشته
    مهندسی شیمی
    نوشته ها
    514
    پسندیده
    0

    [ مورد پسند: 46 بار در 33 پست ]

    پیش فرض Regulation of IL-17 Family Members by Adrenal Hormones During Experimental Sepsis in Mice

    Severe sepsis is a life-threatening disease that causes major morbidity and mortality. Catecholamines
    and glucocorticoids often have been used for the treatment of sepsis. Several recent studies have
    suggested a potential role of IL-17 during the development and progression of sepsis in small animal
    models. In this study, the cross-talk of catecholamines and glucocorticoids with members of the IL-17
    family was investigated during sepsis in C57BL/6 mice. The concentrations in plasma of IL-17A, IL-17F,
    and the IL-17AF heterodimer all were increased greatly in mice after endotoxemia or cecal ligation and
    puncture as compared with sham mice. Surprisingly, when compared with IL-17A (487 pg/mL), the
    concentrations of IL-17F (2361 pg/mL) and the heterodimer, IL-17AF (5116 pg/mL), were much higher
    12 hours after endotoxemia. After surgical removal of the adrenal glands, mice had much higher
    mortality after endotoxemia or cecal ligation and puncture. The absence of endogenous adrenal gland
    hormones (cortical and medullary) was associated with 3- to 10-fold higher concentrations of IL-17A,
    IL-17F, IL-17AF, and IL-23. The addition of adrenaline, noradrenaline, hydrocortisone, or dexamethasone
    to lipopolysaccharide-activated peritoneal macrophages dose-dependently suppressed the
    expression and release of IL-17s. The production of IL-17s required activation of c-Jun-N-terminal
    kinase, which was antagonized by both catecholamines and glucocorticoids. These data provide novel
    insights into the molecular mechanisms of immune modulation by catecholamines and glucocorticoids
    during acute inflammation. (Am J Pathol 2013, 182: 1124e1130
    فايل هاي پيوست شده

    سعید رضازاده (Wednesday 10 April 13)
    افراد موفق کارهای متفاوت انجام نمی دهند، بلکه کار را به صورتی متفاوت انجام می دهند.











اطلاعات موضوع

کاربرانی که در حال مشاهده این موضوع هستند

در حال حاضر 1 کاربر در حال مشاهده این موضوع است. (0 کاربران و 1 مهمان ها)

موضوعات مشابه

  1. پاسخ: 0
    آخرين نوشته: Wednesday 10 April 13, 15:53

مجوز های ارسال و ویرایش

  • شما نمیتوانید موضوع جدیدی ارسال کنید
  • شما امکان ارسال پاسخ را ندارید
  • شما نمیتوانید فایل پیوست کنید.
  • شما نمیتوانید پست های خود را ویرایش کنید
  •